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STAT+: Novo Nordisk stops two cardiovascular trials of drug aimed at lowering inflammation
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关键摘要
诺和诺德终止ziltivekimab两项心血管炎症试验，继ZEUS失败后再度受挫
- 诺和诺德叫停HERMES与ATHENA两项ziltivekimab心血管试验
- 数据监委会认定两项试验 unlikely to succeed
- 此前ZEUS试验已证实该药降炎有效但未降低心梗死亡等临床风险
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正文提要
Novo Nordisk has stopped two trials of a drug that aims to tame inflammation as a way to improve cardiovascular health, another blow for the approach.
The company said it had halted the HERMES and ATHENA trials of its drug, ziltivekimab, after a data monitoring committee found they were unlikely to succeed. Novo informed trial investigators on Friday.
The move follows the earlier failure of the drug in the ZEUS trial, which showed that the medicine, despite lowering markers of inflammation, did not reduce the risk of major clinical complications, including deaths and heart attacks.